Sysiuk Y. Physiological Mechanisms of Antioxidant System Regulation in Cows Organism Depending on Types of Higher Nervous Activity

Іt is very relevant to study the intensity of peroxide lipid oxidation and the activity of the antioxidant system in cows with different types of higher nervous activity. It will deepen existing knowledge of cortical regulation of physiological functions and develop new methods for correcting the intensity of lipid peroxidation and activity of antioxidant defense system taking into account the types of higher nervous activity in cows. Found that cows of weak type of higher nervous activity characterized by the lowest values of the basic properties of cortical processes: strength, balance and mobility (more than in 3 times lower compared with cows of strong balanced mobile type (P<0.01). In animals of weak type of higher nervous activity, the content of lipid hydroperoxides and diene conjugates in blood was by 13.89–15.83 % (P<0.05) and 2.81–7.92 % (P<0.05) respectively to the indicators of animals of strong unbalanced type of higher nervous activity. Regardless of the time of year in cows with a weak type of higher nervous activity, the content of TBA-active products in blood plasma is higher than in cows of strong types. The index of accumulation of lipid peroxidation end products in animals with a weak type of higher nervous activity is lower than the indicators of animals with strong types, regardless of the season, in particular in the summer, is lower than the indicators of animals with strong balanced mobile type by 18.3 % (P<0.05). Reliable relationships have been found between the enzymatic, vitamin links of the antioxidant system and lipid peroxidation products. The dependence activity of superoxide dismutase and glutathione peroxidase in bovine blood, regardless of the season, correlates with the balance of cortical processes (r=0.57–0.60; P<0.05). The activity of superoxide dismutase directly correlates with the strength of cortical processes (r=0.51–0.61; P<0.05), regardless of the season, and with glutathione peroxidase activity – only during the cold season (r=0.57; P<0.05). However, the activity of these enzymes is not related to the mobility of cortical processes. It was established that the content of vitamins A, E and C in blood of cows of different types of higher nervous activity is significantly different and depends on the season. Thus, the content of retinol and tocopherol in blood serum of cows, depending on the type of higher nervous activity, was lower in the cold season by 49.2–55.3 % (P<0.001), 35.8–41.6 (P<0.05–0.001) and 21,7–27,4 % (P<0.001) in comparison with the indicators of these animals during the warm season. The antioxidant factor in animals of strong unbalanced type of higher nervous activity in the cold season is significantly higher by 14.4 % (P<0.05) than in the warm season.