Lyndyna Y. Morphological features of the bone marrow under the heavy metal salts influence

For a complex study of the effects of heavy metals, a design of research was identified which included the use of 84 pubescent white male rats. In order to determine the action of pollutants on the bone marrow and the restorative capacity of hematopoietic tissue, animals had been into two groups divided. Addition of vitamin E to the animal diet was the basis for dividing all the animals into series in order to study the protective properties of the corrector. The study of the main results of the experiment and the rationale for using the corrector for preventive-therapeutic purposes were performed at the expense of modern research methods (microscopic examination of morphological changes of bone marrow in histological, histochemical and immunohistochemical slides, their morphometry, quantitative evaluation of indicators of the chemical composition of hematopoietic tissue, study of indicators of general and biochemical analysis of blood, statistical processing of digital data). On the basis of the results of a comprehensive experimental study, the structural features of the bone marrow of rats were clarified and its key differences from human hematopoietic tissue were determined, both in normal and during the consumption of xenobiotics. This may be the basis for further modeling of changes in hematopoietic tissue when studying the effects of damaging factors. The revealed results demonstrate in detail the fluctuations of hematopoiesis and blood indices during consumption of a mixture of heavy metal salts. The established changes clearly demonstrate the pronounced hematotoxic effect of these xenobiotics upon their excessive admission to the body.