Teslyk T. Morphofunctional Changes in the Lungs under Conditions of Alloxan Hyperglycemia

The thesis is devoted to the study of the influence of alloxan hyperglycemia on the patterns of structural adjustment and changes in the bioelement composition of lungs in animals of different age groups, as well as the possibility of their correction with the drug Quercetin. The chemical compound alloxan monohydrate was used to simulate hyperglycemia. The following research methods were used: lung organometry; morphometry of alveolar structures, components of the aerohematic barrier, pulmonary vessels of muscular type, lymphoid follicles; histological examination of lung tissue; quantitative assessment of lung chemical composition; ultramicroscopic examination of the lungs; instrumental examination of the chest; statistical processing of digital data. Due to the nature of changes in the structures of the pulmonary tissue, and with the aim of correcting the pathogenetic links of the development of alloxan hyperglycemia, the drug Quercetin was selected in the form of granules. In animals on the background of the drug, compared with rats that did not consume Quercetin, stasis in the pulmonary arteries developed later; its immunomodulatory effect contributed to less active hyperplasia of lymphoid follicles, macrophages. These findings provide grounds for the use of Quercetin for the prevention of early and the treatment of initial complications of hyperglycemia.