Bidovanets B. Morphological and Functional Features of the Urinary Bladder of Perimenopausal Women

The dissertation represents the theoretic revision and novel problem solution which establish the histological, ultrastructural and morphometric features of the remodeling of structural components of the urinary bladder layers and its autonomic innervation in women with dysuria in their early and late menopausal periods. The comprehensive anatomic, histological and morphometric characteristics of the structural remodeling features of the urinary bladder of the women in their early and late menopausal periods of nonreproductive ontogenesis phase were supplemented and determined with adequate morphological study methods. The received data from cystometry and urethral pressure measurement proved and expend the concepts on morphological and functional differences of quantitative criteria of detrusor overactivity, filling volume of urinary bladder, urethral functional profile length and its maximal closure pressure in the women in their early and late menopausal periods of nonreproductive ontogenesis phase. The structural realignment of blood vessels and microcirculatory elements in early and late menopausal periods has unidirectional adaptive tendency as the reaction on the remodeling of the urinary bladder wall structures. The structural features of cholinergic and adrenergic innervation of the urinary bladder of the women in early and late menopausal periods were studied and suggested the quantitative and qualitative morphological changes develop in the autonomic innervation of urinary bladder which are the density of cholinergic and adrenergic nervous plexuses. It proves the morphological and functional features of adaptation and decompensation during its remodeling.