Sohuyko R. Morphological peculiarities of the structure, mineral composition of the bone tissue of the mandible in norm and at different terms of opioid exposure and after trauma (experimental study)

In the dissertation study for the first time peculiarities of structure and mineral composition of a bone tissue of a rat mandible body in norm, after prolonged nalbufine use, after its abolition and after bone-destructive trauma to animals without background pathology and on the background of three weeks of opioid use, were studied and analysed in detail on the basis of the data, received as a result of complex research with use of modern morphological and biochemical methods. A complex study of quantitative and qualitative changes in the bone tissue of the mandible on the background of long-term nalbuphine use was performed, and the dynamics of bone density during six weeks of nalbuphine use and after its abolition was studied. A detailed analysis of the mineral composition of the bone tissue of the mandible by atomic absorption spectral analysis was made and the peculiarities of the distribution of macro- and microelements and their dynamics on the background of six-week opioid dependence were determined. The peculiarities of the dynamics and mineral composition of the bone tissue of rats mandible after bone-destructive trauma to intact animals, as well as animals with simulated opioid dependence were studied in detail. A comparison of the post-traumatic dynamics of mandibular bone density and the dynamics of macro- and microelements content in animals without background pathology and animals with opioid dependence was made and their relationship was analysed.