Prokopchuk E. Complex compounds of Sn (IV) with salicyloylhydrazones of benzaldehydes as potential biologically active substances with anti-inflammatory, analgesic and concomitant pharmacological action

The thesis is focused on the investigation of the anti-depressive, anxiolytic, anti-inflammatory, analgesic and anti-convulsive effect of new complex compounds SnCl4 with salicyloylhydrazones benzaldehyde and 4-bromobenzaldehyde when administrated orally. Influence of salicylic acid, benzaldehyde, 4-bromobenzaldehyde and tin ions on pharmacology activity of complexes was ascertained for the first time. Optimal dosage of complex compounds was ascertained to maintain maximum and safe pharmacology effect. Anti-inflammatory activity of new complex compounds SnCl4 with salicyloylhydrazones benzaldehyde and 4-bromobenzaldehyde when administrated orally was ascertained on different models of inflammation (trypsin, histamine, carrageenan and formalin). Investigation of analgetic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and 4-bromobenzaldehyde showed that both complex compounds are effective analgetic remedy with mixed type of receptor interaction. Also components which were investigated for its contribution to functional groups pharmacological activity of complexes also contribute to its analgetic effect. Major contribution to analgetic activity of complex compounds on chemical model of algesia (capsaicin) is done by salicylic acid, indicators of nociceptive reaction statistically was not different from indicators of groups which were receiving reference-drug Ibuprofen. Thus, the study of complex compounds showed that they are promising antidepressants that exhibit pronounced anti-inflammatory, anticonvulsant and analgesic effects.