Dub A. Experimental approach of the antidiabetic activity of the new phytocomposition

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number


Applicant for


  • 14.03.05 - Фармакологія


Specialized Academic Board

Д 64.605.03

National University of Pharmacy


The perception work is devoted to the pharmacological study of a new phytocomposition containing dry extracts of White mulberry (Morus alba L.) leaves, Common bean (Phaseolus vulgaris L.) shells, Bilberry (Vaccinium myrtillus L.) shoots as a promising antidiabetic drug. For the first time, a conditionally effective dose of phytocomposition was set, 165 mg/kg (in the ratio 4.0: 1.5: 1.0 of dry extracts of white mulberry, common bean and bilberry, respectively). Phytocomposition, when administered intragastrically, belongs to the V class of toxicity – almost non-toxic substances (LD50> 5000 mg/kg). It was found that the phytocomposition inhibits the development of insulin resistance and carbohydrate tolerance, exhibits antihyperglycemic, hypolipidemic, antioxidant properties, improves liver function, reduces endogenous intoxication, promotes regeneration of the pancreas and liver in models of metabolic syndrome caused by high-fructose diet and type 2 diabetes mellitus induced by streptozotocin and nicotinamide. Phytocomposition is a promising drug for further preclinical and clinical studies to introduce it into medical practice as a highly effective and low-toxic hypoglycemic and hypolipidemic agent with antioxidant activity for the prevention and treatment of insulin resistance, metabolic syndrome and type 2 diabetes mellitus


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