Varakuta O. Periodontal reactivity in using various dental filling materials in experimental diabetes mellitus (anatomical experimental study)

Based on the comprehensive study results, a holistic picture of morphostructural changes in the "supporting apparatus of the tooth" in diabetes mellitus and in its combination with composite or cement fillings insertion has been provided via assessing the fibrillar architecture of periodontal soft tissues and the microvascular structure of the gingival lamina propria in rats of experimental groups. It has been found that filling insertion had hardly affected the histotopographic characteristics of the periodontium in rats, as all groups of collagen fibrillar structures remained appropriate branching combined with single thin elastic fibers. However, an interesting finding in rats with cement filling compared to the composite group was a significant 16.2 % increase in dentogingival collagen fibers at the 2nd week and a moderate decrease in fibrillogenesis in the animals with the composite one at the 6th week The quantity, topography and lectin histochemical pattern of LCA-antigenpresenting cells and lymphocyte populations (HPA+ -, SBA+ -, PNA+ -, ConA+, SBA+ - В1-lymphocytes) have been first studied as well as CD5+ -, CD20+ -, CD8+ -, CD4+ -lymphocytes in gingival mucosa (epithelium and lamina propria) have been histochemically examined in rats with experimental diabetes mellitus after various chemical types of dental filling material (composite or cement) using. Structural remodeling of connective tissue fibers and periodontal microvasculature in experimental diabetes mellitus or dental filling material presence and in combination of experimental diabetes mellitus with dental composite or cement has been studied in dynamics.