Lutsenko O. Features of the functional state of central hemodynamics in women in different phases of the ovarian-menstrual cycle

The functioning of the human cardiovascular system largely determines the state of health, quality and duration of human life, it is considered an indicator of the state of the body as a whole. It is proved that the characteristics of central hemodynamics, their synchronization, wave manifestations can be reliable predictors of pre-pathological conditions and human mortality. The study found that women aged 18-19 years, both at rest and during various activities, have lower blood pressure, cardiac output compared to men, which may be due to the smaller size of the woman’s body, the general variability of heart rate and stroke. blood, determined by lower levels of blood supply to the thoracic cavity. The effectiveness of spontaneous baroreflex sensitivity in women at rest, and to a greater extent during orthoprobe and during psychoemotional stress, is lower than in men. It is shown that at rest lying down there is an increase in blood pressure and total peripheral resistance in phase III of ovarian-menstrual cycle in comparison with I. During orthoprobe and psychoemotional load there are differences in hemodynamic parameters in phase II in comparison with others, which indicates a more active state of the heart -vascular system in this state. The wave structure of oscillations of the duration of the t-R-R interval and the stroke volume of blood in different phases of ovarian-menstrual cycle is characterized by a decrease in HRV power in the frequency range 0.04 - 0.15 Hz and an increase in the power of UOC oscillations at these frequencies in women in phase III during psychoemotional stress. The amplitude of the maximum peak of the cross-spectral power of UOC and t-R-R oscillations in the range of 0.15 - 0.4 Hz at rest increased in phases II and III compared with I. Under conditions of psycho-emotional load, the largest decrease in this indicator was observed in II (-22,1%) and III (-40.8%) phases according to it’s background level. The found probable correlations between the levels of mean arterial, diastolic pressure and the maximum of cross-spectral power in the range of low heart rate confirm the significant contribution of spontaneous baroreflex sensitivity in maintaining a stable level of hemodynamics. Changes in mean pressure in phases II and III of ovarian-menstrual cycle compared with phase I in women with different levels of muscle component in the body structure at rest while lying down and during orthoprobe. Analysis of the reactivity of the normalized power of the spectrum of oscillations of the interval R-R, blood pressure during ovarian-menstrual cycle indicates different features of changes in the functional state of central hemodynamics and it’s regulation in sympathotonics compared with vagotonics. The study does not cover all aspects of the problem and opens up new opportunities for it’s study. Prospects for further study of the functional state of central hemodynamics in women in different phases of OMC are seen in the conduct of mass measurements on persons with different blood pressure levels and the search for methods of physiological stimuli for its correction.