Burlaka B. Theoretical substantiation of the composition and experimental studies of intranasal dosage forms of cerebroprotective action

The dissertation is devoted to finding a solution to the urgent problem of pharmacy – development of intranasal dosage forms with cerebroprotective effect. The thesis suggests a theoretical concept of the complex methodological approach with the use of information technology, based on which liquid gels with active pharmaceutical ingredients of peptide nature – N-Phenylacetyl-L-prolylglycine ethyl ester (Noopept) and IL-1Ra (RAIL) – have been created. As a result of preclinical studies, their high specific (nootropic, antiischemic, neuroprotective) activity and safety have been shown, as well as their use in the therapy of brain diseases of degenerative and vascular origin has been substantiated. Theoretical basis for the new information technology has been developed, namely the complex methodological approach to creation of the intranasal liquid gels with active compounds of peptide nature demonstrating improved cerebroprotective properties and a high level of safety for systemic use. The results of the experimental pharmaco-toxicological studies of the dosage forms – gels for intranasal administration containing N-Phenylacetyl-L-prolylglycine ethyl ester and IL-1Ra – developed with the help of the new information technology have proven their high cerebroprotective effect, safety and harmlessness and are the substantiation for the first phase of clinical trials.