Mamotenko A. New approaches to the correction of disorders of the adrenocortical and reproductive systems of rats under conditions of changes in the lighting regime

The dissertation is devoted to solving the topical problem of modern physiology – establishing the causal consequences of the destructive effects of long-term changes in lighting mode on the adrenocortical and reproductive systems of rats and the search for integrated approaches to their pharmacological correction. The effect of melatonin and the effectiveness of enhancing its antioxidant and moderating effects due to additional co-introduction of spirulina bioadditive into the diet of rats has been evaluated. It has been found that the introduction of melatonin effectively prevented the development of destructive phenomena caused by changes in lighting, which confirmed the importance of normal secretory function of the pineal gland for the regulation of many body systems, including the adrenal glands. Experimental evidence of the feasibility and high effectiveness of melatonin in hypogonadism, in the pathogenesis of which the main reason has been prolonged melatonin deficiency has been obtained. However, although self-administration of melatonin in experimental animals in the course mode significantly has improved the indicators of morphofunctional state of the endocrine glands, but it has not been completely normalized them. It has been determined that the additional use of spirulina bioadditive has enhanced the protective effect of melatonin, ie there was a synergistic effect. Higher reactivity to melatonin and spirulina has been observed in females. It has been found that a statistically significant decrease in the testosterone/estradiol index in males and its increase in females is evidence of a decrease in the adaptive capacity of the body and an acute response to stress, which is a long-term change in lighting. The high efficiency of the used scheme of course compatible prophylactic use of melatonin in combination with spirulina for preventive reduction of the risk of reproductive disorders in animals of both sexes is being shown. The used scheme of course administration of melatonin in combination with spirulina could be considered as an effective means of preventing the development of hypopinealism and and disturbances of endocrine system which are caused by prolongation of a photoperiod. The scheme of their preventive course introduction, worked out in the work, due to its safety and high degree of protective effects, can be recommended for use in risk groups of light desynchrony. The scheme of their preventive course introduction, worked out in the work, due to its safety and high degree of protective effects, could be recommended for use in risk groups of light desynchrony.