Dzhus M. Reiter's Disease: immunological mechanism of development and diagnosis peculiarities

The dissertation is devoted to the problems of etiology and immunogenesis of Reiter's disease. The original system of evaluation of Reiter"s disease activity was proposed. It was estimated that the most frequent trigger agent is chlamydial infection that often associated with vi-rus infection and also enterobacteria. Immunedependent processes (immune inflammation, genetic and autoimmune processes) are the dominant in the development of Reiter's disease. The disregulation of the cell and humoral immunity in patients with Reiter"s disease is frequent, especially in the HLA-B27 - positive patients. Reduction of the main lymphocytic populations and increasing of immunoregylatory index, IgG, IgA levels and immune complexes were estimated in the HLA-B27 - positive patients versus HLA-B27 - negative patients.