Kulemzina T. Morphology of human's heart with complete transposition of the great vessels

The dissertation is devoted to problem of anatomy of the human heart and histological changes in myocardium with complete transposition of great vessels and presence of accompanying defects. With the help of modem morphological methods is investigated features of an anatomic structure of heart with complete transposition of the great vessels in different age groups, dynamics of changes cavity's anatomic walls and histological changes in myocardium. Complete transposition of the great vessels (CTGV) at viable children is accompanied by other detects with such frequency: opened oval aperture - 61,2%; atrial septal defect - 23,9%; opened arterial duct - 23,9%; ventricular septal defect - 44,8%, anomalies development of great vessels - 14,9%; anomalies development of heart's valves - 9%. The anatomy of heart with complete transposition of the great vessels depends on presence of accompanying defects. Expressiveness and prevalence of histological changes in myocardium (damage of cardiomyocyte and cardioscle rosis) depend on presence of defects and age of a child, and the ratio of compensatory-adaptation and alterative processes in myocardium determines outcome of defect and it's conducting prognostic factor in development decompensation of heart. Revealed morpho-functional of a feature of heart at CTGV will allow to choose optimum alternatives of correction of defect, and also to decide of a question about remodeling myocardial by pharmacological means and to predict postoperative result.