The investigation object: Bone system morphogenesis under the influence of the changes in the organs of the rats’ immune system. The investigation goal: to establish the dependence of the bone morphogenesis of laboratory rats of the different age periods from the condition of reactance of the organs of their immune system at immunosuppression and immunostymulation. The investigation methods: osteometry, organometry, histomorphometry, X-ray crystal analysis, the biochemical analysis (weight, photocolorimetry, atomo- absorptive spectrophotometry); biomechanical research of bone durability; electronic microscopy of the thymus, immunological research of the blood, biochemical research of the blood, research of a level of the content of cortisol, thyroxine and triiodthyronine. The theoretical and practical importance of the received results: the received data reflect features of bone morphogenesis of animals, and also objective laws of influence of organs of immune system on this process. Existing representation about changes of structure and mineral composition of skeleton bones at immunosuppression and immunostymulation is added and expanded. The expediency of the correction, changes developing in elderly age in structure of a bone tissue, by thymogen and cyclophosphanum introduction is substantiated. The carried out research has allowed finding out the separate parts of immunological regulation of bone histogenesis in ontogenesis. The received results have added representation about morphological equivalents of mechanisms of development and realization of the immune answer. Results of the carried out research on nonreproductive, reproductive and animal senile age allow recommending application of thymogen and cyclophosphanum in complex treatment of bone pathology. In connection with that application of immunosuppressive influences on the organism of parents is accompanied by infringements of formation of a skeleton of a fetus, it is necessary to concern with care to prescription to pregnant women, if necessary, the preparations, capable to reduce immunity. The received data can be recommended in practical work of orthopedists - traumatologists of a children's and age pathology, immunologists, obstetricians- gynecologists, hematologists, oncologists at carrying out of measures on treatment of the patients with different forms of diseases, connected with infringement of the immunological status. Results of research can appear useful to a substantiation of stimulation or suppression of rates of growth of a bone tissue in clinical conditions, of interventions on vascular system of a brain. The scientific novelty of the investigation results: In the present research the actual scientific problem in studying morphology of bone system is solved. For the first time objective laws of changes macro-and microarchitectonic, mineral structure, crystallographic and durable characteristics of bones of a skeleton of rats of different age groups in various terms after immunosuppression and immunostymulation are established. Forthe first time in the experiment executed with the help of osteometric, organometric, histomorphometric, biochemical, biomechanical, immunological methods, and also a method X-ray crystal analysis and electronic microscopy are established morphofunctional features of realization of interaction of bone and immune systems, real effects of such interaction are shown. For the first time it is experimentally established, that introduction of thymogen and cyclophosphanum renders positive influence on biomechanical, morphometric and histological parameters of bones of rats of senile age. For the first time research of the structure of long tubular bones periosteum of rats of different age at immunosuppression and immunostymulation is carried out. For the first time features of course of osteogenesis in the neonatal and early postnatal periods at the progeny received from rats which before pairing were exposed to influence of cyclophosphanum, thymogen, cyclophosphanum and thymectomy are established. The degree of implementation: results of research are introduced into educational and scientific process of chairs of human anatomy, operative surgery and topographical anatomy, normal physiology, orthopedics and traumatology of Lugansk state medical university; human anatomy of Vinnitsa National, Odessa, Donetsk, Crimean medical universities, Dnepropetrovsk and Bukovinian medical academies, Uzhgorod and the Sumy universities, histology of Vinnitsa national medical university and the Ternopol state medical academy. Branch of usage: medical sciences, anatomy, immunology, pediatrics, oncology, geriatrics, orthopedics and traumatology.
