Gunchak V. Chronic nitrate and nitrite toxicosis of poultry and its prophylaxis

The object of research - chronic nitrate and nitrite toxicosis, gemopoes, immunogenes, mutagenous action, ionic gomeostas, antioxidized system, oxidized stress, prophylactic action of antioxidant. Targets investigation - to study the peculiarities of course of chronic ni-trate and nitrite toxicosis of poultry; to elucidate the influence of increased quantity nitrates in feeds on metabolic process, morphological and bio-chemical indicators of blood, on immunity system and to substantiate the use of antioxidants for destruction of nitrate toxic action on poultry organ-ism. Methods - pharmacological, toxicological, biochemical, serological blood research, genetic, histological, electronic - microscopic and mathematical. Scientific news - it was substantiated scientifically, exposed and generalized new patogenes aspects of poultry nitrate and nitrite toxicosic (NNT); it was formulated theoretical fundamentals of nitrate toxicodynamic in chicken or-ganism during the chronic course and determined hepatoprotector antioxi-dante action (ascorbic acid, phenaron and methionine). It was demonstrated that in NNT pathogenesis the main role on the cellular level play the processes of freeradical oxygening phospolipides of biological cell mem-brane with the next development of oxygening stress. It was shown and grounded the condition about the taking part of immunity mechanism in supporting chemical gomeostas during NNT. Determine the mutagenous nitrate action after the metaphasecal analysis of bone marrow cells. It was demonstrated a new diagram of NNT progress. It was offered effective methods of gomeostas correction. The degree of introduction - According to the date we have received, it was worked out and confirmed the Industrial Conditions, Instructions "Metio-phene" Application that is used for poultry NNT prophylactic. Some princi-ples of thesis were used in "Methodical references in prophylactic, diagno-sis and animal treatment after nitrate and nitrite intoxication". The test-system of early diagnosis of chronic oc-cult NNT was made up after changing some biological index. Sphere of implementation - is veterinary medicine.