Paschenko Y. Disorders of adaptation-compensation mechanisms in children with intestinal stomas and their surgical correction (experimental-clinical investigation)

Object:intestinal stomas and their complications in children;purpose:to improve the outcome of surgical treatment of the children with intestinal stomas on the grounds of complications systematization,investigation of the etiopathogenetic mechanisms,development of complex diagnostic system,staged surgical correction and rehabilitation at functioning stoma and final reconstructive-restorative operations;methods:general clinical,aboratory,radiological,instrumental,microbiological,experiment,histological,statistical; novelty:for the first time,the concept of priority fields of surgical correction in children with intestinal stomas was formulated;intestinal stoma complications their classification was worked out;the program of post-operative complication prevention at restorative surgical interventions was initiated;results:application of the worked out classification allowed to increase detection of complications up to 81%;the use of the developed algorithms complications diagnosis allowed to predict development of disproportional complications,determine the efficacy of therapeutic measures at evagination and syndrome of prolonged intestine switching off;the developed and introduced techniques of surgical correction allowed to preserve functionally important portions of the intestine promoting improvement of quality of life in future;the developed program of surgical rehabilitation of children with intestinal stomas using the developed techniques and methods 4.3 times reduce the necessity of repeated interventions,reduce the death rate by 16.5% and long-term complications restoration by 9.1%;introduction:medical practice,teaching process;area:medicine.