Kushch O. Morphological patterns of placenta and lymphoid tissue associated with it during the third pregnancy period (anatomic-experimental investigation)

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0508U000482

Thesis Registration Form

0508U000482.pdf

Applicant for

Specialization

  • 14.03.01 - Нормальна анатомія

25-09-2008

Specialized Academic Board

Д 58.601.01

I. Horbachevsky Ternopil State Medical University

Essay

The thesis is devoted to the descision of normal anatomy scientific problem, concerning of placenta and placenta associated lymphoid tissue structure patterns. Reactivity of placenta associated lymphoid tissue on antigen influence is shown. Role of dendritic cells in establishment of immunological tolerance is examined. Intimate correlation between morpho-functional state of placenta and amount of lymphocytes is settled. Innate immunity chain depended on lectinreceptor recognition is described. We have examined peculiarities of women and rats’ placenta morphogenesis during the third period of pregnancy, depending of activation of different immunity chains. It is settled, that dendritic cells activate at the end of pregnancy when connective zone of placenta turns thinner and number of cytotoxic lymphocytes increases. All these lead to regection of immunological tolerance of maternal organism in relation to foetus. Antigen influence notwithstanding direction of influence, weather it is on maternal or foetal organism, results in the changes adoptive functions of placenta. Revealed changes of morpho-functional condition of placenta take place on the background of placenta associated lymphoid tissue changes, which points on activation of innate immunity.

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dis Kusch O.G--dis 9--Vusnovku.doc

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