Pryshlyak A. Morphofunctional peculiarities of the adaptative and disadaptive changes of cardiac muscle in toxic lesions

The dissertation is devoted to the complex morphological study of adaptative and disadaptive processes peculiarities in the experimental animals cardiac muscle under cadmium chloride and carbon tetrachloride influences on their organisms. The theoretical generalization of structural and functional features differences of the myocardium in white rats depending on their sensitiveness to hypoxia were shown. The longterm carbon tetrachloride and cadmium chloride effects on the animal organisms were revealed to result in the prominent morphological transformations of the myocardium on all the structural levels of its organisation. The essential growth of the cardiac portions mass, the chambers dilatation, increase of relative volumes of the stromal structures, the injuried cardiomyocytes and endotheliocytes, decrease of ventricles reserve volumes, secretory activity of atrial cardiomyocytes, capillary-cardiomyocytic ratio, reduction of the arteries throughput, afferent and exchanging links of haemomicrocirculatory bed, the venous part dilatation, endothelial disfunction and hypoxia were found out. In the prolonged poisoning of the animals by the above mentioned chemicals more pronounced structural transformations in the cardiac parts are likely to prevail in the white rats with low resistance to hypoxia.