Karpova I. Lectins as factors of influence on mutagenesis

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0509U000263

Applicant for

Specialization

  • 03.00.15 - Генетика

30-04-2009

Specialized Academic Board

Д.26.202.01

Essay

The subject of study is the process of spontaneous and induced mutagenesis; the aim is to reveal the peculiarities of the mutagenesis regulation with help of lectins, an important and widely occuring proteins that bind carbohydrates; the novelty - lectins of different structure, physical/chemical properties and carbohydrate specificity demonstrated their ability to modulate spontaneous and induced mutagenesis both in mammalian and bacterial cells. These effects are dependent on the repair system of the cell. The fundamental studies are combined with practical work focused on lectins from medicinal plants as indicators of disease-associated deviations in reactions receptor-lectin caused by pollution of environment. These deviations are supposed to provide the specific reason for correction of some deviations with help of lectin-containing plants.

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