Shatorna V. The morphogenetic laws of the embryogenesis heart development

The dissertation is devoted to the problem of morphogenesis mechanisms of the developmental anomalies of heart caused by hypoxia and hyperthermia action finding-out. The terms of formation of heart diseases under the influence of hypoxia or hyperthermia and morphological reorganizations which lead to formation of developmental anomalies of heart were studied in experimental models. Structural changes in different heart part during the embryogenesis are quantitatively estimated: auricles, ventricles, atrio-ventricularis the channel, atrio-ventricularis valves, interatrial and interventricular partitions, cono-truncal department and valves of the big vessels of heart. For revealing of infringements during base hystohgenesis processes were used imunohystohemical markers. The accumulation of proliferation markers Кі-67 and apoptosis bcl-2 gave the chance to compare proliferation-apoptosis processes in norm and to reveal changes in models of experiments. The accumulation of a marker of stressful fiber НSP allowed to trace the formation of protective reaction of an albuminous component in fabrics of heart after it was influenced by hypoxia or hyperthermia. Revealing of terms and process stages vasculogenesis or its infringements became possible thanks to CD to a 34-marker of endothelia and a marker – ?-sma of a smooth muscular fabric. The teratogen influence in different embryogenesis intervals has defined the terminal period’s presence in cardiogenesis when direct dependence of septachion processes from influence of physical factors is observed.