Pogorelov M. Morphofunctional characteristics of bone repair under the overhydratation type of the water-salt disorders

The investigation of morpho-functional features of reparative osteogenesis in normal and new nanocomposite material using chitosan-apatite under the overhydratation type of the water-salt disorders in the age aspect. Structural and functional features of reparative regeneration of the long bones were studied by methods osteometry, histomorphometry, blood biochemistry, scanning electron microscopy with microanalysis, PIXI-analysis, spectrophotometry and determination of hardnessparameters of bone and bone tissue. In this paper the delay in the regeneration of long bones of the skeleton at overhydratation in animals of all ages. Major changes are observed while the animals of the elderly. Violation of regeneration begins with changes in cellular composition of the hematoma and intercellular interactions that leads to the violation of tissue ratio in the following stages of osteogenesis and the forming callus disabled. Chitosan-apatite as a replacement material for bone defects is expressed osteointegrative and osteoconductive properties. Using the implant had no impact on processes of regeneration stages and even slightly accelerated the process of calcification of the organic matrix, which may indirectly indicate the presence of osteoinductive properties of the material. Use of porous nanocomposite material on the background of overhydria leads to minor violations of hardness parameters of injured bones, possibly associated with their optimal salinity entering the implant. Given the integration of material breach and regenerate the structure, changes in the exchange of bone under hypoosmolarity overhydratation is necessary to conduct the correction of violations of water-salt metabolism before the implantation of chitosan biopolymer-apatit.