Moroz G. Adrenal glands, thymus and spleen structure regularities under the hypergravity exposure (anatomical and experimental study).

The dissertation deals with identification of morphogenesis of the adrenal glands, thymus and spleen of juvenile, young and mature rats, subjected to systematic gravitational overloads and during treatment with glutargin. There was found that at rats, subjected to 10 seances of gravitational accelerations, structural and functional changes in the examined organs, regardless of age the animals, were stressfull. Adaptive-compensatory reactions are adequate and ensure the safety of the organism immune status. After 30 seances in juvenile and young rats transition of functional adaptation to the trophoplastic leads to the formation of a stable adaptive system. In mature adult rats state of the adaptive response reflects the instability caused by a combination of the adverse effect of accelerations and involutive changes, contributing to the chronic stress development. After 45 seances of the gravitational overloads direct damaging effects of the hypergravity forces come to the fore, consisted in the growth of destructive and dystrophic changes in the organs. The level of adaptation processes, especially in adult mature animals does not meet the increasing needs of the organism, leading to imbalance of regulatory mechanisms in young rats, and to the adaptation failure – in mature adult rats. Using of the glutargin as an antioxidant and membrane-stabilizing agent to provide correction of the morphological changes in the adrenal glands, thymus and spleen and to enhance their adaptive capacity for systematic effects of gravitational overloads was proved morphologically for a short administration course (10 days) only.