Fomina K. Morphogenesis of the neuroendocrine system in normal environmental conditions and after inhalation of ecologically unfavorable volatile components of epoxy resins in different age periods

The dissertation is devoted to the study of the morphological and functional features of neuroendocrine system structure of white lab male rats of different age periods in normal ambient conditions, after a two-month inhalation of the main volatile components of epoxy resins (epichlorohydrin and toluene), after the use of drugs with a complex antioxidant action (synthetic - Thiotriazolin, floral - tincture of Echinacea purpurea) and combined experimental influences. The paper used a complex of modern morphological studies: physiological, macroscopic description of organs, organometry, histomorphometric analysis, optical and electron microscopy, cytological, biochemical, mathematical and statistical. In the brain, the hypothalamus, pituitary, thyroid and adrenal glands the morphological changes at the organ, tissue, cellular and sub-cellular levels of the organization were identified and characterized in details, the hormonal status of the animals was monitored. Found that the intensity, direction and duration of the identified morphological changes depend on the age of rats, the type of the factor and the timing of rehabilitation.