Gasiuk P. Structural and functional organization of enamel and histotopografic different classes of teeth and large salivary glands of man.

The dissertation is devoted to the study of histofunctional and histotopografical structural features of enamel and major salivary glands of human and to the theoretical grounding of enamel biomineralization processes on the stages of histogenesis. It was shown that during embryogenesis of enamel the primary biomineralization is caused by the production of preameloblasts nanosferyts. Secondary biomineralization process is characterized by the formation of enamel prism by two types of differentiated ameloblasts, thixotropic replacement of enamel proteins by hydroxyapatite crystals. Tertiary enamel biomineralization is provided by oral fluid which due to the features of сytostructure of striated ducts cell enriched with organic and inorganic compounds which by the way of its penetration into the surface layers of enamel and subsequently through lamellas, form enamel sheaves, forming Rettsiuz lines of biomineralization. It was set that in plots of Rettsiuz lines heads of enamel prisms form smectic form, in the prism enamel heads and tails have nematic form, and in without prism enamel crystals form a cholesteric structure of liquid crystal. It was proved that tynktorial character of secretory granules of acinar glandulotsyts tends to change at different functional activity of the salivary glands. It was found that in the large salivary glands local protective barrier is represented by plasma cells, macrophages and intraacinar interstitium and also macrophages and mast cells in periductul connective tissue.