Fomina S. Immunomediated treatment of glomerulonephritis with nephrotic syndrome in children.

Dissertation provides the new scientific decision an actual problem to slow the Chronic Kidney Disease progression in nephrotic children by developing the principles of immunotropic therapy and predicting the disease course. Risk factors of relapsing disease course and Chronic Kidney Failure were identified in 1459 nephrotic children with 60 months follow up period during years 1980-2011. The disease pathomorphosis was found in years 2001-2011 compared to previous twenty years. The proposed optimization of treatment depending on an initial sensitivity to steroids includes the consistent use of prednisolone, chlorambucil, cyclophosphanun and mycophenolate mofetyl. New approach to the investigations the renal function and hemodynamic (including the tests of creatininuria, ?2-microglobulinuria, urinary renospecific enzymes activity, dynamic and static renoscintigraphy results) was created. The multimarker parallel cascade system for prediction unfavorable disease course was created.