Khokhlenkova N. Theoretical and experimental basement of pharmaceutical development of drugs on base of oak bark for treatment of wound process

The thesis is devoted to developing new technologies of substances of natural origin – dense oak bark extract (DOBE) and the creation of ointments, plaster and medical pad from DOBE for the integrated treatment of wounds, inflammatory skin diseases, burns middle scale. For the first time using modern physico-chemical methods of analysis, studies of oak bark to harmonize national legislation requirements for oak bark with the requirements of the European Pharmacopoeia were conducted. A monograph «Oak bark» is developed and included in the SPU. A comprehensive study was aimed at creating a standardized national substance of natural origin – DOBE. Based on the physico-chemical, technological, biopharmaceutical, biological studies theoretically and experimentally composition and rational technology of ointments «Biotanin», «Biofloryn» bactericidal plaster of DOBE and medical pad «Algikord» are developed intended for the treatment of wounds, inflammatory diseases, skin burns middle scale. Methods of quality controls are developed; stability and pharmacological activity are studied. A physico-chemical, technological and biopharmaceutical research experimental designs ointments, plaster and medical pad are developed.