Morozenko D. Pathogenetic role of the connective tissue metabolic disturbances, informativaty of its showings for the diagnostics and estimation of the effec-tiveness of dogs and cats internal organs treatment

Object of research - internal diseases of dogs and cats. A research objective - to prove a pathogenic role of metabolic disorders of connective tissue, and set the verbosity of its indicators for the diagnosis and evaluation of the effectiveness of treatment of domestic dogs and cats in internal medicine. Research methods: clinical, biochemical, tools (sonography, X-ray) and statistical. Scientific novelty: the first found that when dogs pneumonia and bronchial asthma cats disturbed glycosaminoglycans (GAGs) metabolism and excretion of hydroxyproline, which may indicate the degradation of collagen structures in the bronchi. Is theoretically justified mechanisms of gastroenteritis in dogs and cats, causing the increase in the serum content of glycoproteins and GAGs decreased concentration and stability excretion of hydroxyproline and uronic acid indicates a lack of catabolism of collagen and proteoglycans. It was established that in the pathogenesis of liver diseases in dogs and cats is important to develop fibrosis that is characterized by impaired catabolism of collagen and proteoglycans connective tissue. Chronic glomerulonephritis in dogs increases serum levels of glycoproteins, sialic acid, chondroitinsulfates and heparansulfate, increases the excretion of hydroxyproline and uronic acids, which may be due to progressive fibrosis of the glomeruli and interstitium and development of disturbances in proteoglycan synthesis in the liver with the nephrotic syndrome. Clinically justified mechanisms of increased catabolism of collagen and proteoglycans in cats with diabetes mellitus. Clinically proven that the dynamics of changes in the parameters of the connective tissue after treatment of dogs and cats due to a decrease in the activity of inflammation and slowing fibrosis of internal organs. Implemented: the results of research are used in research and teaching in the faculties of higher educational institutions III-IV accreditation levels to practice veterinary medicine clinics. Materials included in the dissertation one textbook, two textbooks, monographs and guidelines. Sphere (branch) of use: veterinary medicine