Kovalenko S. Theoretical and experimental study of composition and technology of combined drugs on the basis of sulfurorganic acids.

For the first time scientific methodological approach to the creation of the combined medicines on the basis of sulfurorhanic acids for the treatment of diabetic complications was substantiated. For the first time it was established, that combination of thioctic acid and taurine shows a synergistic effect of antioxidant and membrane stabilizing activity, which increases the effectiveness of its pharmacotherapy use for correction of metabolic disorders in patients with diabetes. For the first time, using a systematic approach, complex approach to the definition of social and medical appropriateness, efficiency and commercial appeal in the development of a new drug was proposed and applied. Based on comprehensive research compositions and technologies of original medicines for the treatment of diabetic complications were scientifically confirmed: "Tiotarin" film-coated tablets and gel "Tialan". Quality indicators, listed in the analytical and technological reference documentation for the developed drugs, taking into account the hardware-specific processing equipment industries, were substantiated and experimentally validated. Methods of quantitative determination of the active components of tablets and gel were developed and validated.