Kostenko S. Species specific characteristics of genomic instability and polymorphism Sus scrofa and Bos taurus by cyto- and DNA-markers

The thesis is devoted to the complex molecular genetic evaluation of species-specific genome plasticity Sus scrofa , and Bos taurus based on cytogenetic and DNA polymorphism. Comparison of intraspecific polymorphism and intrabreed S. scrofa , and B. taurus for cytogenetic somatic mutagenesis in different radio-ecological conditions involving constitutive chromosome rearrangements indicates the highest reactivity karyotype domestic pig, reflecting the rapid evolution and stability of the karyotype of this species. New data on polymorphism micropopulations Large White pigs for 12 genes associated with economic-useful traits. For the first time the specific features of polymorphism micropopulations tribal and commodity stocks Large White pigs on the estrogen receptor gene. Established polymorphism of different breeds of pigs for genes melanocortin receptor 4 (MC4R), estrogen receptor (ESR), follicle-stimulating hormone receptor (FSHR) and prolactin receptor (PRLR), follicle-stimulating hormone ? (FSHB), nuclear coactivator A1 (NCOA1). Scientifically justified use of complex genotypes to improve reproductive qualities of pigs. A system approach for estimation the gene pools of domestic breeds of pigs (S. scrofa) on the basis molecular genetic and cytogenetic markers on the example of large white breed, which involves identifying animals with stable cytogenetic somatic mutagenesis (aneuploidy, micronucleus, chromosomal aberrations) and carriers of economically valuable genotypes gene ESR, PRLR, FSHR, MYF4, MC4R, FUT1, MUC4, C-MYC and RYR was preposed