Nefedova O. Morphogenesis of effects of the isolated impact of lead acetate and their combined action with metals citrates to embryogenesis and development of rats hart (anatomical and experimental study)

The dissertation researches devoted to defining the morphogenesis of the isolated effects influence of ultra-low doses of lead acetate and lead acetate combined action of citrate metals (gold, silver, iron) on the general course of embryogenesis and development of embryos rats heart in the experiment. By using morphological methods studied embryotoxic and teratogenic effects of these substances when they are isolated and combined administration throughout pregnancy. Experimentally determined increase in the total embryonic mortality (in 2.16 times) in isolated administration of lead acetate and lower embryonic mortality in groups of combined effects. Using morphometric and microscopic methods of research spectrum disorders found in isolated cardiogenesis lead acetate administration, determined ventricular myocardium thinning compact (7,9 % left, right 11,2 %), ventricular septal thinning and reducing the thickness fibrillation with developmental delays trabeculae. In groups of combined effects identified the modifying effect of metal citrate to cardiotoxicity of lead acetate, determined that restoration of compact myocardium thickness of the walls of the ventricles, the absence of violations by the formation of valvular and ventricular septal.