Nebesna Z. Morphofunctional changes of lungs in experimental thermal trauma and in the conditions of correction.

The thesis is devoted to determining of peculiarities of lungs rebuilt in experimental thermal trauma, and its correction with lyophilized xenographt substrate and surfactant. In experiment on white laboratory rats it was found that severe burn trauma causes considerable morphological, histochemical, immunohistochemical and morphometric changes in the lungs, degree of which depends on term of experiment and are developing at the background of oxidative stress and systematic violations of metabolism in the course of endotoxemia increase. Using of xenographt substrate after early necrectomy of burn damaged of tissues prevents development of destructive changes of the lungs at early terms of experiment, activizes regenerative processes, which helps to normalize relatively vasculature, bronchi, components of the respiratory portion at later stages of experiment. Using of surfactant after thermal trauma has positive effect on the respiratory components of the lungs that result in the structural upgrade of the alveoli. The combined using of substrate of xenographt and surfactant after thermal trauma has the most positive impact on morphofunctional condition of the lungs, especially in the later stages of experiment. Corrective factors, especially in their combined using after burn, significantly improves the functions of enzymatic link of antioxidant protection, significantly reduces the manifestations of endogenous intoxication syndrome and relieble reduces the of oxidative stress activity manifestations.