Aishpur O. Theoretical and experimental ground of development of facilities of specific prophylaxis of swine bacterial respiratory diseases

In dissertation work at first in Ukraine, theory and experimentally reasonably, technology of development of vaccine is made and inculcated for a specific prophylaxis the most economically meaningful swine bacterial respiratory diseases in the period of their growing and fattening on the basis of clinical, epizootological and laboratory researches (bacteriological, serum, molecular-genetic, biological experiment). Materials of dissertation work are devoted to the analysis of swine bacterial respiratory diseases course in Ukrainian pigfarms, theoretical-experimental ground and development of specific prophylaxis means. It is set on the basis of the conducted researches, that bacterial respiratory swine diseases plays an important role in infectious pathology of pigs and need new means of its specific prophylaxis. It was conducted epizootological and pathoanatomical monitoring and it was set high percent of respiratory diseases among the herds of large pigfarms of Ukraine. The infectious nature of pneumonias is confirmed and the role of particular agents in a pathological process was studied. The immunological monitoring of the Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae the basic agents of swine bacterial respiratory diseases was conducted and it is proved Mycoplasmas pneumonia and Actinobacillus pleuropneumoniae agents be associate circulated among the population of domestic and wild pigs. In theory and optimal composition of antigens is experimentally reasonable for constructing of vaccine against most spread disease – Glasser’s disease, Salmonellosis and Oedema disease. In the complement of vaccine «Gaemoenterotoksal» is entered immunogenic and antigen active straines of bacteria, namely: H.parasuis 5747; H.parasuis ША; E.coli 1084 О139:К81; E.coli 1297 О157:К88; Salm. choleraesuis S32; Salm. typhimurium Skp. Construction of the bacterial associated vaccines against bacterial respiratory diseases was developed and that provided theoreticaly base for the development of the vaccine. The «Gaemoenterotoksal» vaccine against the most widespread swine diseases – Glasser’s disease, Salmonellosis and Oedema disease was created. It was proved efficiency the vaccine at acute infectious process in large pigfarms.