In qualifying scientific work due to the complexity of the executed medical - social research an actual scientific problem is decided - based on fundamental investigations, developments of international and national professional societies as well as the results of its own study performed at the regional level and based on the concept of personalized medicine,it is proved and developed innovative and systematic set of prognostic, organizational and technological algorithms and tools for organizational- legal support for structural-functional model of health care (HС) for bronchopulmonary dysplasia (BPD) with the implementation on national, regional and family levels. The dissertation is done within using evidence-based methods and methodology of social medicine, phasing and consistency in solving tasks in the study it is received credible results, significant for the theory of social medicine and practice of health care for child population, including children born prematurely. It is proved that identification of high risk of BPD is possible as stratification of regional - population groups, so as personalization of available REF and medical-social risk factors in the condition of use of the most informative prognostic value of them based on predictive algorithms for population monitoring and perinatal screening. It is proved that the influence of heredity on the formation of BPD is only 46.0%, while the medical-social risk factors and REF - 54.0%, that grounds the development of regional preventive programs and health promotion models for regional health care systems. The results of information-entropy analysis demonstrates that the elimination/modification of the most significant impact on the whole MSF is able to ensure the effectiveness of primary prevention of BPD at the level of 20,0?23,0%, while modification of the five most significant MSF - at 35?39%. It is substantiated and verified a criterial algorithms for quantitative determination of children (Y, persons) requiring HC in regional centers for diagnosis and treatment of BPD, which estimates interdependence between the prevalence of prematurely born children in a particular region and the frequency of BPD in the population, characterized by polynomial dependence Y = -0,40k2 + 5,1k-1,83 and allows high accuracy (R2> 0,96, p <0.04) to determine the estimated annual prevalence of BPD. It is proved that taking into account the regional structure of newborn body weight (BW) gives opportunity to plan reliably the volume of HC need by using of specially elaborated algorithms and quantitative appropriate nomograms. The multiobjective algorithm is grounded and the criteria of meta-assessment of HC efficiency for prematurely born on the base of generalized indicator of medical aid efficiency (GIE) in a particular facility (or group of facilities) are defined and software and information instruments (software "Neomed-BPD") are developed for implementation of regional monitoring of effectiveness of neonatal care, taking into account the frequency of BPD, its exits and the personification of periods of gestation, BW at birth, the severity of bronchopulmonary dysplasia. It is proved, developed, implemented and evaluated the effectiveness of SFM of health-care for BPD at the regional level based on the principles of personalized medicine, in particular its scientific and organizational, regulatory support, health promotion technologies on regional level personalized health, medical and social technologies (predictive algorithms of BPD risk assessment on the base of complex REF and MSF in the structure structural-functional model).
