Levytska O. Clinical and pharmaceutical substantiation of conceptual model of drug supply for patients with acute cerebrovascular accidents

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0521U100918

Applicant for

Specialization

  • 15.00.01 - Технологія ліків, організація фармацевтичної справи та судова фармація

16-04-2021

Specialized Academic Board

Д 35.600.02

Danylo Halytsky Lviv National Medical University

Essay

The objects – the assortment of drugs for pharmacotherapy of acute cerebrovascular accidents, their pharmacoepidemiological, marketing, economic, pharmacoeconomic and expert assessment, assortment-reimbursement characteristics within the government program "Affordable Medicines"; information on the quality of life of people who had acute cerebrovascular accidents; the purpose – substantiation of the conceptual model of drug supply of patients with acute cerebrovascular accidents based on the results of clinical and pharmaceutical studies; methods – comparison, generalization, modelling, systematic, bibliosemantic, content, clinical and epidemiological, frequency (including FMR); ABC -; VEN (VED)) analysis; ATC / DDD analysis; DU 90% analysis, graphical and mathematical methods of assessing the competitiveness of drugs, marketing, pharmacoeconomic, indicator analysis, expert assessments, determining the availability of drugs; analysis of wholesale prices for medicines; survey using the SF-36 questionnaire; mathematical and statistical analysis; results – were to substantiate and summarize the results of the research that solves an important scientific and applied problem – improving the quality of medication for patients with acute cerebrovascular accidents in the health care system of Ukraine. Clinical and epidemiological features and consumption of drugs in acute cerebrovascular accidents, antiplatelet and statin market analysis, assortment and reimbursement of clopidogrel and simvastatin within the government program "Affordable Medicines", economic availability of drugs for pharmacotherapy of ischemic stroke and their expert evaluation, pharmacoeconomic evaluation of dual antiplatelet therapy in acute small ischemic stroke have been studied. Evidence-based data on thrombolytic, antiplatelet and statin therapy for ischemic stroke have been systematized. The competitiveness of tenecteplase according to alteplase were determined. A quantitative assessment of clinical indicators of the quality of medical care for ischemic stroke associated with the use of drugs and an assessment of the quality of life of persons who had acute cerebrovascular accidents have been done. A model of optimization of drug supply and a model of quality management of medical care for patients with acute cerebrovascular accidents in terms of pharmacotherapy was created; introduced – into the practical work of pharmaceutical and medical organizations and the scientific and educational process of higher education institutions of pharmaceutical and medical profiles; branch – pharmacy.

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