Zhmurchuk V. Clinical and pathogenetic features and prognosis of asthmain children on the background of iron deficiency

3 First data about negative impact of iron deficiency on the development, severity and level of control of asthma in children based on results of comprehensive examination of 227 asthmatic children aged 6-17 years and 40 healthy children. The diagnostic value of serum iron levels, total and latent iron-binding capacity of serum, level of iron transferrin saturation, serum ferritin, soluble transferrin receptors, the ratio of soluble transferrin receptors to ferritin were proved in the progression of asthma in children and their effect on external respiration. Significantly (p <0.05) lower indicators of external respiration function were established for the first time: forced vital capacity of the lungs (FVV), forced expiratory volume in 1 second (FEV1), Tiffno Index, peak volumetric expiratory velocity (PFV) in the group with iron deficiency compared to normal iron content and iron deficiency without anemia. For the first time, new data have been obtained to increase the efficiency of predicting the severity of the course and the ability to control asthma in children by determining the role of individual indicators of erythrocyte indices and iron metabolism. For the first time, it was found that persistent severe asthma on the background of iron deficiency was observed four times more often compared with children with persistent mild and moderate asthma. In children with asthma, levels of the disease control were correlated with iron deficiency degrees. Thus, in patients with iron deficiency without anemia, the uncontrolled course of asthma was observed 4.8 times more often compared with children who had a normal iron content. There was an uncontrolled course of asthma in patients with iron deficiency in 100% of cases.