Byelousova I. The pathogenetical substantiation of pharmacocorrection of hypoxic syndrome by xanthine derivatives.

The thesis is devoted to the pathogenetical substantiation of pharmacocorrection of HS, formed in conditions of an influence on an organism acute hypoxic hypoxia and hyperthermia by xanthine deriva-tives. Is established, that the highest pharmacoprophylactic efficiency for want of given pathological condition among all investigated xanthine derivatives exhibits pentoxifylline for want of it enteralic intro-duction by an experimental animal in a doze of 150 mg/kgs 1 hour prior to effect of the extreme factors, for want of the average therapeutical doze of a preparation has made 120 mg/kgs. Is shown, that in the basis of an antihypoxic operation of a preparation the ability it to prevent ac-tivation of processes of peroxidizing oxidation phospholipids membrane lies. That is exhibited in decrease of the contents of primary, intermediate and final products lipidperoxidation. The important role in reali-zation by a preparation of an antihypoxic operation is played it by antiradical properties confirmed by a method BCL. Besides the important significance has pentoxifyllines ability to increase in fabrics a level of endogenic protectors of hypoxia - cАMP and prostacycline. Significant influence to formation and the current of HS renders pentoxifyllines ability to prevent violation of antioxidanting-prooxidanting balance at the expense of preservation of activity of such com-ponents of the antioxidanting protective system of an organism, as catalase, SOD, glutatione, and preven-tion of decrease of the contents of the functional active SH-groups, and also to provide a sufficient level of protection of an organism from effect of the extreme factors owing of membrane stabilizer operation estimated on peroxidizing stability of erythrocytes membranes.