Podpletnya O. Influence of non-narcotical analgesics on lipid peroxidation in the structures of brain in rats in condition of acute pain.

The dissertation is dedicated to the research of influence of non-narcotical analgesics on the state of lipid peroxidation in the structures of brain in rats in order to determine mechanisms of the central component of pain-relieving action of acetylsalicylic acid, diclophenak-natrium, indometacin and amison.(1/10 LD 50) the drug shows pain-relieving and anti-oxidative properties. By the ability to interfere with functional state of the central nerves system (emotional and behavioral activity, memory) and by parameters of changes in the system of lipid peroxidation in different structures of brain non-narcotical analgesics do have an effect on the nerves system. This data is implemented into the programs in the . 3. Used methods: method of electrical stimulation of rat's tails, method of studying of behavior in the "open field", conditional reaction of passive escape, biochemical methods of studying of the concentration of products of lipid peroxidation and the activity of enzymes of the antioxidant p rotection. We obtained experimental data showing certainty of the processes of lipid peroxidation in the structures of brain while acute over-threshold pain stimuli are applied. We have proved the importance of the role of lipid peroxidation in neocortex both in conditions of acute pain and while using non-narcotical analgesics. We have determined the dose-dependent and anti-oxidizing effects of the new non-narcotic amison. These effects of the drug are most prominent when it is used in dose of 8.6 mg/kg (1/40 LD50); when used in dose of 34.5 mg/kg department of pharmacology and clinical pharmacology in Dnepropetrovsk state medical academy, National medical university, Poltava medical dental academy, National pharmaceutical academy of Ukraine, Vinnitsa, Lugansk and Odessa state medical universities.