Shayakhmetova G. Experimental evidence for acetate-2,5,7,8-tetramethyl-2-(4-methylpenten-3-yl) -6-oxichromane application under the chemical lesion of liver

The dissertation concerning data on protective effect of a-tocopherol derivative with a truncated side chain under the chemical lesions of liver caused by prooxidative xenobiotics is defended. No differece was demonstrated in antioxidative activites of both a-tocopherol and its truncated derivative, that was the evidence for a hydroxyl group in tocopherol chromanol ringe to play a key role. It was revealed the ability of an a-tocopherol derivative to prevent a depletion of an antioxidative system. Also, the high antioxidative efficiency as well as stabilization of membrane-bound enzymes activities which result in maintaining a liver structure-functional homeostasis were shown. It provides the necessity for the development of methods for both prevention and treatment of toxic lesions in liver which potentiate lipid peroxidation, based on application of acetate-2,5,7,8 - tetramethyl-2-(4-methylpenten-3-yl)-6-oxichromane.