Kabanova T. Antiaggregants, derivatives of linear peptidomimetics and heterocyclic compounds.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U000412

Thesis Registration Form

0401U000412.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

15-01-2001

Specialized Academic Board

Д 41.600.01

Odessa National Medical University

Essay

The antithrombotic properties of 1,4-benzodiazepine derivatives, and piperidine- and pirrolidinediones were investigated. It was established a distinct antihaemostatic and antiaggregative activities equal to these of acetylsalicylic acid or higher ones. Antihaemostatic and antiaggregative effects of gidazepam and aspirine combinations were investigated. The low dose combination 1:1 was recognized as the most effective. The novel linear RGD-peptidemimetics exhibited high antiaggregatory potency, the mechanism of their action was proved to be them the antagonists of fibrinogen receptors.

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