Dobrovolskij V. Antifibrillatory effect of vasothrophic and analgetic remrdies (experimental study)

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U001581

Applicant for

Specialization

  • 14.03.05 - Фармакологія

23-05-2002

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The dissertation is devoted to revealing of presence antifibrillatory effect of vasothrophic and analgetic remedies. Pentoxyphyllin, Dipyridamol, Nicergolin, Aspisol (А), Bensofurocain (В), Tramadol (Т) show antifibrillatory properties. Antifibrillatory effect of A, B, T at postischemic reperfusion of coronary artery at anesthetized cats exceeds similar Amiodaron action in 1,8 times. Thus T in the greater degree warns mitochondria damage, A - keeps structure of a nucleus, B - considerably expands T-system channels of sarcoplasmic reticulum.

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