The object is 1,5-3-months age calves of the black-white breed, rabbits of chinchillabreed chinchilla by age 15-16 months; the aims to consists in study of biochemical structure and functional properties calves' erythrocytes, patients kataral bronchopneumonia, and their change at treatment with antibacterial preparations use; the methods are clinical, pathology-anatomical, morphological (erythrocytes, leukocytes) and biochemical (hemoglobin, hemiglobin, population structure of erythrocytes and their acid resistance, lipid structure of erythrocytes? membranes: general lipids, cholesterol and phospholipids; the contents of general and inorganic phosphorus and 2,3-diphosphogliycerat in erythrocytes, general albumen and albuminous fractions, activity asparagin and alanin transamin?s, urea, creatinin) research of blood, microbiological - bronchial slime; the new approach lies on the basis of study of lipids? structure of erythrocytes membranes venous and arterial blood clinically healthy calves and contents in them of 2,3-diphosphogliycerat the more proof connection of oxygen with hemoglobin in venous blood and less proof - in arterial is reasonable. Increase of quantity "young" erythrocytes in blood of the bronchopneumonia sick calves at initial stages of disease, in comparison with clinical healthy ones, and the intensive increase of a population of "old" cells at the further development of a pathology characterizes an exhaustion of compensatoryopportunities of marrow at an animal with a heavy degree of current bronchopneumonia. The increase of hemiglobin concentration (methemoglobin) in blood of the bronchopneumonia sick calves is, obviously, consequence of decrease of activity antioxygen of processes both in erythrocytes of blood, and in bodies. At the bronchopneumonia sick calves the changes of lipid structure of erythrocytes? membranes (reduction of contents of lipids) and stehiometrical ratio between cholesterol and phospholipids in membranes are revealed, that specifies infringement albumen-lipids of connections of bilayer and results in decrease of stability of red cells of blood. The increase of activity of 2,3-diphosphogliycerat of the shunt glycolysis of erythrocytes is compensatory mechanism of increasing hypocsical hypoxia. The negative influence Amoxicilini trigidrati on erytron system is established: the contents of lipids components decreases and their ratio in erythrocytes membranes is broken, that is displayed on albumen-lipid connections bilayer; develops hypochromia anemia, which results in increase hypoxia, the function of a liver is broken urea-formation function and the functional ability renal glomuluses is reduced; the main is developed diagnostics of various degrees of current bronchopneumonia and circuit treatment of the sick calves; all this thesis аre introduced "The Recommendations concerning application of Amoxicilini trigidrati 15 %-s' for treatment calves, with bronchopneumonia" authorized SSII of veterinary preparations and fodder additives; the field is Veterinary Medicine.
