Shatyrkina T. Catecholaminergic mechanisms of analgesic action non-opioid analgesics

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U003893

Thesis Registration Form

0402U003893.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

18-12-2002

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The dissertation is devoted to one of actual in a modern medical science the problem of pain and regulation of painful sensitivity that expands representation about mechanisms of action non-opioid analgesics, in particular at a painful syndrome. It is revealed, that in formation of a visceral painful syndrome and realisation antinociceptive effect of amizon, mefenaminum sodium and, to a lower degree, paracetamol take part alfa2-,beta2-adrenoreceptors and D2-dopamine receptors. Catecholaminergic system takes part in formation of painful syndromes which are caused an inflammation and infringement of nerves. Changes of functional activity adrenergic system do not depend from ethyology pain, and dopaminergic - differ depending on genesis pain. Amizon results in increasing of functional activity adrenergic and in decreasing of functioning dopaminergic systems.

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