Mametova A. Experimental estimation of protective action of mildronate and riboxine in modelling of cerebrovascular disorders (experimental research)

The dissertation is devoted to investigation of the cerebroprotective effects of mildronate and riboxine in the conditions of rocking of the animals in the antiorthostatic position and to the experimental justification of use of these drugs for the prophylaxis and correction of the cerebrovascular disorders caused by action of extreme factors upon an organism, that is accompanyed by increase of the hydrostatic pressure of blood and liquor as well as by vestibulo-vegetative disorders. It has been experimentally founded out that mildronate and riboxine in the conditions of rocking in the antiorthostatic position lead to correction of the blood flow and vascular reactivity, possess significant antiedematic, antihypoxant activity, reduce acidosis, promote restoration of the prooxidant-antioxidant balance. While action of the drugs the significant positive changes have been revealed in pathomorphological state of the brain caused by long-lasting rocking in the antiorthostatic position. They are manifested mainly by the cytoprotective effect. The combined use of mildronate and riboxine amplify their antihypoxant and antiedematic effects. The obtained results of the investigation allow to assert that mildronate and riboxine possess significant cerebroprotective effect in modelling of the cerebrovascular disorders with the help of rocking in the antiorthostatic position. The cerebroprotective effect of the drugs is caused, first of all, by the corrective influence upon different links of energetic metabolism. This gives evidence of good perspectives of their use not only in space form of motion sickness, but also in other types of vascular pathology of the brain