DOROSHCHUK V. Stimulation of the reparative regeneration of the bone skin in the time of the bone crashes

The object of investigation was the process of bone tissue reparative regeneration in dogs with bone fractures of the peripheral skeleton. The aim of the study was establishing the effective methods of stimulating the bone tissue reparative regeneration in dogs with bone fractures. Methods used in the study were both clinical, blood morphology (erythrocytes, leucocytes, leucogram) included, morphological (roentgenography), biochemical (alkaline phosphatase activity, calcium, phosphorus, strontium, manganese content in blood serum), histological (morphological peculiarities of a regenerate at various stages of the process; the slides were stained with hematoxylin and eosin), and statistical. Scientific novelty: the possibility of enhancing the process of bone tissue reparative regeneration using preparations which stimulate this process was experimentally substantiated; the part played by certain cell elements in osteogenesis was established. The dynamics of changes in biochemical indices, micro- andmacro-elements in animal blood in the period of bone fracture adhesion was established, as well as its connection with osteogenesis stages duration. To stimulate the reparative osteogenesis in dogs, we were the first to : a) use embryonal osteogenic tissue; b) experimentally establish the peculiarities of metabolism and course of bone tissue reparative regeneration effected by thiotriazolin; c) approbate the "Supradyn" preparation as a stimulant of the reparative regeneration in dogs. Recommended: We suggest using the complex of preparations chymotrypsin, thiotriazolin, "Supradyn", "Ostim-100" and embryonal osteogenic tissue to heal the bone fractures in dogs. Introduction: Our study results and recommendations have been introduced into the treatment practice of our veterinary clinic. Besides, the results achieved in the clinic have been introduced into the process of teaching subject "Veterinary Surgery". Sphere of application: veterinary medicine.