Kryghnaya S. The search and pharmacological learning of the derivatives of sukcinic acid, which shows antihypoxic activity

For the first time antihypoxic activity 23 of the derivatives of sukcinic acid is investigated. The expediency of the search in the series of compounds with expressed antihypoxic operation is taken for granted. The substance is select „thiazolilamidaetan", which advantage is greater in 29.4 times antihypoxic index to mexidol. Its proof antihypoxic activity is established at preventive introduction on different models of acute hypoxias. The usage of thiazolilamidaetan is more effective than mexidol: thiazolilamidaetan positively influenced a course of chronic dependent of oxygen. The researched substance and adaptive mechanisms of organism. Are installed different sorts of biological operation of the thiazolilamidaetan. In a chronic experiment thiazolilamidaetan did not render the negative influence on the function of corganism. The obtained data thiazolilamidaetan are starting for further pre-clinical research of this substance as potential medical resource with antihypoxic operation.