Yevtushenko O. Pharmacological analysis of the central neurotransmitter mechanisms of the antiepileptic drugs' action.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U001664

Thesis Registration Form

0405U001664.pdf

Applicant for

Yevtushenko Olga

Specialization

14.03.05 - Фармакологія

Date of defense

20-04-2005

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

In the dissertation the possibility of the individual approach in the antiepileptic drugs prescribing dependently on the neurotransmitters' profile of their action is grounded. Taking into account neurotransmitter profiles of the mechanisms of the studied antiepileptic drugs' actions, the optimum combinations - depakine and lamotrigine, carbamazepine and topiramate were grounded. These combinations appeared to be the most effective against seizures caused by GABA metabolism disturbances. With the use of quantum chemical method the correlation between antiseizure activity of phenobarbital, carbamazepine, depakine, lamotrigine, felbamate and the energy of the system's interaction of these drugs with aminoacid residue Thr201-Thr202-Gly203- Ala204-Tyr205-Pro206 of GABAA receptor was found out.

Thesis supervisor

Gromov Leonid

Official opponents

Кокшарева Наталія Володимирівна
Кульчицький Олег Костянтинович

Files

DIS_1.doc

DIS_2.doc

Ris-ris 4_1.doc

Ris-ris 4_2.doc

Ris-ris 4_3.doc

Ris-ris 4_4.doc

Ris-ris 6_1.doc

Ris-ris 6_2.doc

Ris-ris 6_3.doc

Ris-ris 6_4.doc

Ris-ris 6_5.doc

Ris-ris 6_6.doc

Ris-ris 6_7.doc

Ris-ris 6_8.doc

Ris-ris 6_9.doc

Ris_straniza91.doc

Ris_straniza92.doc

Yevtushenko_aref.doc

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