Object of investigation - pathology of kidney in high-productive cows and neonatal calves; the goal of the investigation consists in the experimental and idealized substantiation of methods of diagnostic the nephrotic syndrome in high-productive cows, and also in calves with colibacteriosis; the investigation method - clinical, physical (relative density and hydrogen ionization value, value of a hematocrit); microscopical (erythrocytes, leucocytes of a blood, urocheras); biochemical (protein, urea, creatinine, glucose, activity of GGT in serum of a blood and urine, residual and azote of amino acids, common lipids and cholesterol, fractions of protein, activity AST and ALT in serum of a blood); bacteriological (allocation and identification of bacterias from kidney and urine); pathohistological (kidney); the scientific novelty is, that physiological limits of indexes for the first time are established, which one characterize excretory, filtrational, reabsorbtion and concentration functions of kidney inhigh-productive cows and neonatal calves, that is the basis for diagnostic of nephropathology. The nephrotic syndrome in high-productive cows is characterized by disturbance excretory, filtrational, reabsorbtion and concentration functions of kidney, hypoproteinemia, hypoalbuminemia, proteinuria, glucosuria and hyperazotemia, decrease of level the urea and creatinine in urine. A structure of microflora, secured of kidney and urine of cows for the first time is investigated at hepatorenal syndrome, the correlative connection between quantity of bacterias in urine and intensity of proteinuria, glucosuria, ascending of activity GGT and quantity of leucocytes in urocheras is established. For the first time is demonstrated, that the decreasing of allocation the urea and creatinine with urine can serve indicator of disturbance filtrational, excretory and reabsorbtion functions of kidney in cows with hepatorenal syndrome. As for 100 per cent of dairy cows the decrease of a concentration index of a creatinine and reabsorption index is marked, therefore they can be esteemed as informative indexes for diagnostic of hepatorenal syndrome. Is established, that the level of a filtrate nitrogen and urea in serum of a blood can not serve objective yardstick of diagnostic of hepatorenal syndrome. The morpho-functional dismaturity of kidney in calves 3-5-days of age predetermines a high level of glucosuria and proteinuria. The level equalization of a urea in serum of blood from 5-day's age, residual and azote of amino asids, factor of concentration of urea - with 15-day's, quantity of a creatinine, value of concentration index of a creatinine and reabsorption index - from 20-day's age grows out of gradual acclimatization excretory, filtrational and reabsorption functions of kidney to conditions of after born season of ontogenesis. For the calves with colibacteriosis, the glomerulonephritis develops, that is characterized retentional hyperazotemia, basically owing to detention of egestion urea, hypercreatyninemia, proteinuria and glucosuria owing to disturbance of filtrational function of glomerulis of nephrons and reabsorptional - of canals; suggested: yardstick of diagnostic nephrotic and hepatorenal syndromes in high-productive cows and nephrotic syndrome in calves with colibacteriosis, and also scheme of treatment of ill calves; inculcated: the outcomes of researches, which one are set up in dissertation, have come in the tutorials "Clinical diagnostics of animal's diseases" and "Veterinary clinical biochemistry", which one are approved by the Ministry of agrarian policy of Ukraine as the tutorials for opening-up of specialists in agrarian higher educational establishments III - IV levels of accreditation on direction 1305 "Veterinary medicine", and are included in the methodical guidelines "Biochemistrical methods of researches of the animal's blood", approved by the order of State department of veterinary medicine of Ministry of agrarian policy of Ukraine № 115 from 07.10.2004; using area: Veterinary Medicine.
