Kizub I. Pharmacological analysis of glycolysis and electron transport chain blockers influence on pulmonary arteries hypoxic constriction (experimental study).

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U002597

Thesis Registration Form

0405U002597.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

15-06-2005

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The effects of glycolysis and electron transport chain blockade on rat pulmonary artery contractile activity were studied under hypoxic condition in intact, denuded and myoendothelial electrical coupling blocked isolated vascular rings. The data suggest that pulmonary artery hypoxic contraction is endothelium-dependent and it is likely that glycolysis and electron transport chain in endothelium cells contribute to hypoxic pulmonary vasoconstriction via myoendothelial gap junction by means formation and conduction of depolarizing electrical signals from endothelial cells to smooth muscles that caused their contraction under hypoxia.

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Files

Kizub_aref.doc

Kizub_diser.doc

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