Yanitska L. The study of biochemical mechanisms of the rat brain membrane structures damage under the chloroalkanes intoxication and nicotinamide treatment

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U003672

Thesis Registration Form

0405U003672.pdf

Applicant for

Specialization

  • 14.01.32 - Медична біохімія

15-09-2005

Specialized Academic Board

Д26.003.07

Essay

The dissertation deals with the study of biochemical mechanisms of the rat brain membranes structures injury under conditions of 1,2-dichlorоethane and tetrachloromethane acute intoxication. The biochemical and morphological investigations were performed in 24 and 48 hours after toxins administration. It was shown that following 48 hours after intoxication both the brain synaptosomes vesicles serotonin transport system, Na+,K+-ATPase and mitochondrial succinate dehydrogenase activities were drastically alterated. The monoamine transport system and membrane-bound enzyme activities alteration was accompanied by the significant shifts in brain lipids fatty acids composition and brain tissue and erythrocytes membranes lipids and proteins peroxidative modification. The treatment of rats with nicotinamide (200 mg/kg body weight) resulted in considerable normalization of rat brain biochemical and ultrastructural disturbances induced by chloroalkanes acute intoxication.

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Files

Автореф.doc

Дисертація-ост.doc

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