Nekrut D. The role of insulin-like growth factor-1 and hydrogen sulfide in the mechanisms of progression and correction of non-alcoholic fatty liver disease, associated with hyperhomocysteinemia.

Object - mechanisms of steatogenesis and fibrogenesis in non-alcoholic fatty liver disease associated with hyperhomocysteinemia; aim – to establish the role of insulin-like growth factor-1 and hydrogen sulfide in mechanisms of the progression of experimental non-alcoholic fatty liver disease associated with hyperhomocysteinemia in rats and to substantiate pathogenetic approaches to its correction by lipid-lowering agents with polytrophic properties; methods – biochemical, immuno-enzymatic, pathophysiological, pharmacological, morphological, statistical; results – for the first time, a complex study of biochemical mechanisms of the progression of non-alcoholic fatty liver disease associated with hyperhomocysteinemia was made, and approaches to pathogenetic correction of lipid-lowering agents with polytrophic properties; mechanisms of progression of non-alcoholic fatty liver disease associated with hyperhomocysteinemia are realized through the factors of "multiple impact" potentiation of oxidative stress, suppression of antioxidant activity, increased proinflammatory stimulation and suppression of production of antifibrotic modulators; for the first time it was established that with non-alcoholic fatty liver disease associated with hyperhomocysteinemia, a significant H2S deficiency in the liver is formed and the serum level of IGF-1 decreases; the features of the influence of lipid-lowering agents with polytropic properties on the level of antifibrotic mediators in conditions of non-alcoholic fatty liver disease associated with hyperhomocysteinemia were first established; It is shown that the preparation of omega-3 polyunsaturated fatty acids helps normalize the level of H2S in the liver and IGF-1 in the serum, and also helps to lower the level of homocysteine in the blood; branch – medicine.